Gene drive is an exercise of stimulating biased inheritance of particular genes to alter entire populations. Possible alterations include adding, disrupting, or modifying genes, including some that reduce reproductive capacity and may root a population crash. Prominently, gene drives function only in sexually reproducing species, so they cannot be used to engineer populations of viruses or bacteria. Some alleles have evolved molecular mechanisms that confer them greater transmission chance than the normal 50%, which confers them gene drive properties. Synthetic genetic modules with analogous properties have been established as a powerful technique for genome editing of in-vivo populations. It has been recommended as a technique for changing wild populations, for instance to conflict insects that spread diseases (in particular mosquitoes in the cases of malaria and zika), to control invasive species, or to eradicate herbicide- or pesticide resistance. Numerous molecular mechanisms can arbitrate gene drive. This admission focuses on endonuclease-based gene drive, the supreme versatile and actively emergent molecular backend for synthetic gene drives. It must be duly noted that the term gene drive denotes to both the principle of biasing allele inheritance and to the genetic elements highlighting a biased inheritance (i.e. a piece of DNA). Because it is a way to artificially bias inheritance of desired genes, gene drive set up a major change in biotechnology. The potentially huge impact of releasing gene drives in the wild nurtures major bioethics concerns regarding their development and management. Gene drives has a potential to spread a trait across through an entire population — potentially even eradicating an entire species. But, evolutionary powers are going to change even the super best-engineered plans. A powerful and controversial new application for genetic engineering: GENE DRIVES is now discovered by novel scientists. Gene drives can force a trait through a population, challenging the usual rules of inheritance. A specific trait customarily has a 50-50 chance of being passed along to the next generation. A gene drive could push that degree to nearly 100%. The genetic dominance would then linger in all future generations. Gene drives may work in some species that reproduces sexually, and they have the potential to revolutionize disease control, agriculture, conservation and many more. Scientists influence can be able to stop mosquitoes from spreading malaria, for example, or exterminate the invasive species. The technology characterizes the first time in history that humans have the capability to engineer the genes of a wild population. As such, it raises an intense ethical and practical concern.