Nanoengineering is the exercise of engineering on the nanoscale. It originates its name from the nanometre, a unit of quantification equalling one billionth of a meter. Nanoengineering is largely a synonym for nanotechnology, but accentuates the engineering rather than the pristine science aspects of the field. By utilizing nano-engineering as an implement researcher shows that a micromotor fueled by stomach acid can take a bubble-powered ride inside a mouse. These minute motors, each about one-fifth the width of a human hair, may bid a safer and more efficient way to distribute drugs or diagnose tumors. The incipient motors aimed controlling and enhancing site-categorical distribution in the gastrointestinal (GI) tract, consist of dihydrogen monoxide-powered magnesium-predicated tubular micromotors coated with an enteric polymer layer. The microscale robot can allocate lade to particular location through dissolution of their enteric polymeric coating to activate their propulsion at the target site towards localized tissue perforation and retention. The enteric coating can shield the motors from an acidic gastric fluid environment (pH 1–3) but dissolves in intestinal fluid (pH 6-7) to expose the motors to their fuel and commence the kineticism. Tuning the thickness of the pH-sensitive coating it is feasible to selectively activate the propulsion, at desired regions of the GI tract, and thus to control their localized tissue perforation and retention. Our in vivo results demonstrate that these micromotors can safely pass through the gastric fluid and accurately activate in the GI tract without causing conspicuous acute toxicity. They calculated the properties and functions of the synthesized enteric magnesium micromotors in a mouse model. The in vivo results demonstrate that these motors can safely pass through the stomach and accurately activate in the GI tract without causing salient acute toxicity. Our micromotor-predicated GI conveyor system offers innovative cumulation of precise situating and active propulsion towards efficacious localized GI distribution and amended retention in the GI tract. These developments are of particular paramountcy for the emerging microbiome research.